全天PK10北京计划在线免费计划

网站地图 联系我们 │ │ 内部网English |
全天PK10北京计划在线免费计划 所况简介 机构设置 科研队伍 院地合作 党群园地 国际交流 博士后 研究生教育 信息公开
科研进展
成果报道
最新重要论文(影响因子PNAS及以上)
发表论文数据库
所级学术报告
科学成果
发表论文
专著
专利
获奖
专题
所史丛书
所庆专辑
建所50周年画册
现在位置:全天PK10北京计划在线免费计划 > 科研进展 > 最新重要论文(影响因子PNAS及以上)
Dual-targeting nanoparticle vaccine elicits a therapeutic antibody response against chronic hepatitis B, Nature Nanotech, 2 Mar 2020
2020-03-02 | 【     】【打印】【关闭

Nature Nanotechnology2 March, 2020,DOI:

Dual-targeting nanoparticle vaccine elicits a therapeutic antibody response against chronic hepatitis B

Wenjun Wang, Xiaoxiao Zhou, Yingjie Bian, Shan Wang, Qian Chai, Zhenqian Guo, Zhenni Wang, Ping Zhu, Hua Peng, Xiyun Yan, Wenhui Li, Yang-Xin Fu & Mingzhao Zhu

Abstract

全天PK10北京计划在线免费计划Chronic hepatitis B is caused by prolonged infection with the hepatitis B virus (HBV), which can substantially increase the risk of developing liver disease. Despite the development of preventive vaccines against HBV, a therapeutic vaccine inducing an effective antibody response still remains elusive. The preS1 domain of the large HBV surface protein is the major viral attachment site on hepatocytes and thus offers a therapeutic target; however, its poor immunogenicity limits clinical translation. Here, we design a ferritin nanoparticle vaccine that can deliver preS1 to specific myeloid cells, including SIGNR1+ dendritic cells (which activate T follicular helper cells) and lymphatic sinus-associated SIGNR1+ macrophages (which can activate B cells). This nanoparticle vaccine induces a high-level and persistent anti-preS1 response that results in efficient viral clearance and partial serological conversion in a chronic HBV mouse model, offering a promising translatable vaccination strategy for the functional cure of chronic hepatitis B.

文章链接:

相关报道:http://www.hnshb.com/kyjz/zxdt/202003/t20200301_5507177.html

 

       
版权所有:中国科学院生物物理研究所     京ICP备05002792号 京公网安备 110402500011 号
地址:北京市朝阳区大屯路15号(100101) 电话:010-64889872
意见反馈联系人:侯文茹 电子邮件:houwenru@ibp.ac.cn